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Adverse effects include addiction, memory problems, paranoia, difficulty sleeping, teeth grinding, blurred vision, sweating, and a rapid heartbeat. Deaths have been reported due to increased body temperature and dehydration. Following use people often feel depressed and tired. MDMA acts primarily by increasing the activity of the neurotransmitters serotonin, dopamine, and noradrenaline in parts of the brain. It belongs to the substituted amphetamine classes of drugs and has stimulant and hallucinogenic effects.
MDMA was first developed in 1912 by Merck. It was used to enhance psychotherapy beginning in the 1970s and became popular as a street drug in the 1980s. MDMA is commonly associated with dance parties, raves, and electronic dance music. It may be mixed with other substances such as ephedrine, amphetamine, and methamphetamine. In 2016, about 21 million people between the ages of 15 and 64 used ecstasy (0.3% of the world population).
MDMA stimulates the release of the neurotransmitters such as serotonin from brain neurons, producing a high that lasts from 3 to 6 hours, but its length can be variable based on the user. The drug’s rewarding effects vary with the individual taking it, the dose, purity, and the environment in which it is taken. Repeat doses are often used in the sane day or night.
MDMA can produce stimulant effects such as an enhanced sense of pleasure and self-confidence and increased energy.